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A 52semanas se observa reduccin del volumen circulante y de la presin arterial, en relacin con la reduccin de adipoquinas y aldosterona, acompaado de disminucin de albuminuria y aumento de filtrado glomerular respecto a placebo, sugiriendo beneficio renal aadido47

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Currently, GPx3 is considered a new tumor-suppressor gene [23], and its hypermethylation, which is associated with the further down-regulation of GPx3, was observed in patients with Barretts esophagus [54], endometrial adenocarcinoma [55] and prostate cancer [56]

Glucagon suppression: GLP-1 reduces the release of glucagon, a hormone that tells the liver to release stored glucose